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QNZ46

SKU: orb1223374

Description

QNZ46 is a NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases.

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Key Properties

CAS Number1237744-13-6
MW443.41
Purity>98% (HPLC)
FormulaC24H17N3O6
SMILESCOc1cc2c(cc1)nc(n(c2=O)c1ccc(cc1)C(=O)O)/C=C/c1cc(ccc1)[N+](=O)[O-]
TargetMEK
SolubilityDMSO : ≥ 4.5 mg/mL10.15 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

QNZ46 | QNZ-46 | QNZ 46

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  • QNZ46 [orb1305595]

    99.65% (May vary between batches)

    1237744-13-6

    443.41

    C24H17N3O6

    5 mg, 10 mg, 25 mg, 100 mg, 50 mg, 1 ml x 10 mM (in DMSO), 200 mg
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QNZ46 (orb1223374)

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Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 90.00
10 mg
$ 140.00
25 mg
$ 250.00
50 mg
$ 440.00
100 mg
$ 710.00