Quetiapine Fumarate

SKU: orb1226964

Description

Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.(In Vitro):Quetiapine (<100 μM; 24 hours) has no significant effect on cell viabilities.Quetiapine (10 μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner.Quetiapine (10 μM) also inhibits TNF-α synthesis.(In Vivo):Quetiapine (10 mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination.

Images & Validation

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Key Properties

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CAS Number	111974-72-2
MW	883.09
Purity	>98% (HPLC)
Formula	C₄₆H₅₄N₆O₈S₂
SMILES	C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C(=C/C(=O)O)\C(=O)O
Target	5-HT Receptor
Solubility	DMSO: 36 mg/mL (40.76 mM)

Bioactivity

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In Vivo

Quetiapine (10 mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination. Animal model: C57BL/6 mice. Dosage: 10 mg/kg/day. Administration: Ingested. Result: Significantly increased in optical density of myelin basic protein (MBP) staining compared to Veh group.

In Vitro

Quetiapine (<100 μM; 24 hours) has no significant effect on cell viabilities. Quetiapine (10 μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner. Quetiapine (10 μM) also inhibits TNF-α synthesis. Cell Viability Assay Cell line: N9 microglial cells. Concentration: 0, 0.1, 1, 10, 50, and 100 μM Incubation time: 24 hours. Result: Had no significant effect on cell viabilities at various concentrations under 100 μM, in which significant toxicity could be observed. RT-PCR Cell line: N9 microglial cells. Concentration: 10 μM. Incubation time: 24 hours. Result: Dramatically inhibited TNF-α synthesis.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ICI 204636

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Gene Symbol

5-HT Receptor

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