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R-8507

SKU: orb1692097

Description

R-8507 is a small molecule TNF-αRI antagonist that inhibits TNF-α- and IL-1β-induced ICAM-1 expression in A549 cells. It blocks TNF-αRI internalization by disrupting RIP1 and TRADD interactions, making it a useful research tool for studying inflammation and cell signaling pathways in vitro.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number338773-13-0
MW348.71
FormulaC16H8ClF3N4
SMILESFC(F)(F)C1=NC2=CC=CC=C2N2C(=NN=C12)C1=CC=C(Cl)C=C1
TargetOthers,IκB/IKK,RIP kinase,TNF,Interleukin

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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R-8507 (orb1692097)

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