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Repinotan

SKU: orb1688104

Description

Repinotan (BAY x 3702) is a brain-penetrant, selective 5-HT1A receptor agonist with neuroprotective properties. Its research applications include studies of acute ischemic stroke and traumatic brain injury, where it has demonstrated in vivo efficacy in models of neuroprotection and opioid-induced respiratory depression.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number144980-29-0
MW400.49
Purity99.00% (May vary between batches)
FormulaC21H24N2O4S
SMILESO=C1C=2C(S(=O)(=O)N1CCCCNC[C@@H]3OC=4C(CC3)=CC=CC4)=CC=CC2
Target5-HT Receptor

Bioactivity

Target IC50
5-HT7 Receptor:6 nM (Ki)|5-HT1A Receptor:0.25 nM (Ki, rat and human cortex)|5-HT1A Receptor:0.59 nM (Ki, rat hippocampus)|5-HT1A Receptor:0.19 nM (Ki, calf hippocampus)
In Vivo
Repinotan (1-100 μg/kg) induces a strong, dose-dependent reduction in infarct size in permanent and transient middle cerebral artery occlusion, as well as in traumatic brain injury paradigms.
In Vitro
Repinotan affects the anti-apoptotic protein Bcl-2, serotoninergic neurotransmitter glial growth factor S-100beta, nerve growth factor, and inhibits caspase-3 activity via MAPK and PKCα pathways .

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BAY x 3702 free base, 5HTReceptor, 5HT Receptor, 5-HT1A

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Key Properties

No computed properties available.

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Repinotan (orb1688104)

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Available Sizes

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1 mg
$ 340.00
5 mg
$ 770.00
10 mg
$ 1,030.00
25 mg
$ 1,560.00
50 mg
$ 2,020.00
DispatchUsually dispatched within 6-8 weeks
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