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RIPK1-IN-19

SKU: orb2565350

Description

RIPK1-IN-19 is a potent and selective bimodal inhibitor of RIPK1 (IC50=15 nM) that effectively blocks necroptosis. It has demonstrated protective efficacy in preclinical models, including TNFα-induced Systemic Inflammatory Response Syndrome (SIRS) and imiquimod-induced psoriasis, supporting its use in inflammation and cell death research.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2763831-43-0
MW496.54
Purity98.81%
FormulaC28H25FN6O2
SMILESC(N[C@@H](C)C1=CC(F)=CC=C1)(=O)C=2C=3C(N(C)C2)=CC=C(C3)C4=CC=5N(C=C4)N=C(NC(=O)C6CC6)N5
TargetRIP kinase

Bioactivity

Target IC50
RIPK1:15 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

RIPK1-IN-19 (orb2565350)

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1 mg
$ 110.00
5 mg
$ 210.00
10 mg
$ 310.00
25 mg
$ 570.00
50 mg
$ 890.00
100 mg
$ 1,170.00
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