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Rivastigmine

SKU: orb1310812

Description

Rivastigmine

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number123441-03-2
MW250.34
Purity99.85%
FormulaC14H22N2O2
SMILESCCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C
TargetCholinesterase (ChE)
SolubilityDMSO:70 mg/mL (279.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.99 mM)

Bioactivity

Target IC50
ChE:5.5 μM
In Vivo
Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition.
Cell Research
Chronic toxicity is assessed 7 days after continuous exposure of cells to donepezil or rivastigmine using cell viability and cell esterase activity and the estimated cell numbers as parameters for viability. Culture medium including the tested drugs is changed once after 4 days.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Rivastigmine, S-Rivastigmine, SDZ-ENA-713, SDZ-ENA 713, SDZ-ENA713, parasympathomimetic, Parkinson's, orally, inhibit, Inhibitor, Exelon, AChE, acetylcholinesteras, Alzheimer's, BBB, BChE, butyrylcholinesterase, ChE, Cholinesterase (ChE), cholinesterase, cholinergic, disease

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Key Properties

No computed properties available.

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Rivastigmine (orb1310812)

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% DMSO +
%+
% Tween 80 +
%

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25 mg
$ 90.00
50 mg
$ 100.00
100 mg
$ 130.00
200 mg
$ 150.00
500 mg
$ 180.00
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