RPS6KA5 (N) Antibody, Rabbit Polyclonal

SKU: orb131733

Description

Rabbit polyclonal to RPS6KA5. Ribosomal protein S6 kinase alpha-5 (RPS6KA5) belongs to the protein kinase superfamily, the AGC Ser/Thr protein kinase family, and the S6 kinase subfamily. RPS6KA5 is a serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. RPS6KA5 phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Additionally, RPS6KA5 plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression.

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:1000-1:3000
Reactivity	Human
Application Notes	WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human RPS6KA5.

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human RPS6KA5
Molecular Weight	90
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Concentration	100 μg/ml BSA
Disclaimer	For research use only

Alternative Names

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anti Ribosomal protein S6 kinase alpha-5 antibody, anti S6K-alpha-5 antibody, anti 90 kDa ribosomal protein S6 kinase 5 antibody, anti Nuclear mitogen-and stress-activated protein kinase 1 antibody, anti RSK-like protein kinase antibody, anti RSKL antibody, anti MSK1 antibody

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UniProt

O75582

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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