(S)-p38 MAPK Inhibitor III

SKU: orb1694606

Description

This cell-permeable methylsulfanylimidazole compound is a potent and selective p38 MAP kinase inhibitor, exhibiting an IC50 of 0.90 μM in enzymatic assays. It effectively suppresses pro-inflammatory cytokine release, specifically TNF-α and IL-1β, from human PBMCs with IC50 values of 0.37 μM and 0.044 μM, respectively, making it a valuable tool for inflammation and signal transduction research.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	581098-48-8
MW	404.5
Formula	C₂₃H₂₁FN₄S
SMILES	S(C)C=1NC(=C(N1)C=2C=C(N[C@@H](C)C3=CC=CC=C3)N=CC2)C4=CC=C(F)C=C4
Target	p38 MAPK,Others

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

10938334 ↗

Key Properties

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No computed properties available.

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