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SBI-0206965

SKU: orb1306418

Description

SBI-0206965 is a selective, cell-permeable inhibitor of the autophagy-initiating kinase ULK1, with an IC50 of 108 nM, and also inhibits ULK2 (IC50 = 711 nM). This tool compound is widely used in vitro and in vivo to investigate the fundamental role of autophagy in cancer, neurodegenerative diseases, and metabolic disorders.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Images & Validation

Key Properties

CAS Number1884220-36-3
MW489.32
Purity99.13%
FormulaC21H21BrN4O5
SMILESCNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
TargetApoptosis,Autophagy,AMPK
SolubilityDMSO:257.5 mg/mL (526.24 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.09 mM)

Bioactivity

Target IC50
ULK2:711 nM|ULK1:108 nM
In Vitro
In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Unc-51 like kinase, ULK1, ULK, SBI 0206965, SBI0206965, SBI-0206965, Apoptosis, Autophagy, inhibit, Inhibitor

Similar Products

  • SBI-0206965 [orb1225827]

    >98% (HPLC)

    1884220-36-3

    489.3192

    C21H21BrN4O5

    10 mg, 50 mg, 100 mg, 25 mg, 1 g, 500 mg, 200 mg, 2 mg, 5 mg
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Key Properties

No computed properties available.

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Protocol Information

SBI-0206965 (orb1306418)

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% DMSO +
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% Tween 80 +
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Available Sizes

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2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 150.00
25 mg
$ 220.00
50 mg
$ 330.00
100 mg
$ 490.00
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