Cart summary

You have no items in your shopping cart.

Schisantherin A

SKU: orb1222003

Description

Schisantherin A, also known as Gomisin C, is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera with anti-inflammatory properties.(In Vitro):The concentrations of TNF-α and IL-6 in the supernatant of cells pretreated with 2.5 or 25 mg/L of Schisantherin A are significantly decreased compared to the LPS control group (p0.05). LPS causes a significant increase in lung wet/dry weight ratio (p<0.01) compared with the control group. Schisantherin A dose-dependently decreases the lung wet/dry weight ratio (p<0.05) compared to those in the LPS group.
Read more...

Images & Validation

−
Schisantherin A

Key Properties

−
CAS Number58546-56-8
MW536.57
Purity>98% (HPLC)
FormulaC30H32O9
SMILESC[C@@]1([C@H](Cc2cc3c(c(c2c2c(cc(c(c2OC)OC)OC)[C@@H]1OC(=O)c1ccccc1)OC)OCO3)C)O
TargetOthers
SolubilityDMSO : ≥ 100 mg/mL 186.37 mM; H2O : < 0.1 mg/mL

Bioactivity

−
In Vivo
Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been reported to possess varied beneficial pharmacological effects. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Pretreatment with Schisantherin A markedly ameliorates LPS-induced histopathologic changes and decreases the levels of TNF-α, IL-6 and IL-1β in the BALF. In addition, the phosphorylation of NF-κB p65, IκB-α, JNK, ERK and p38 induced by LPS are suppressed by Schisantherin A. The lung wet/dry weight ratio is evaluated at 7 h after the intranasal instillation of LPS. The results show that there are no differences between control group and Schisantherin A (40 mg/kg) group (p>0.05). LPS causes a significant increase in lung wet/dry weight ratio (p<0.01) compared with the control group. Schisantherin A dose-dependently decreases the lung wet/dry weight ratio (p<0.05) compared to those in the LPS group.
Read more...
In Vitro
The concentrations of TNF-α and IL-6 in the supernatant of cells pretreated with 2.5 or 25 mg/L of Schisantherin A are significantly decreased compared to the LPS control group (p<0.05, p<0.01). The potential cytotoxicity of Schisantherin A is evaluated by the MTT assay after incubating cells for 24 h in the absence or presence of LPS, result shows cell viabilities are not affected by the cytokines at concentrations used (0.5, 2.5, 25 mg/L). RAW 264.7 murine macrophage cells are pre-incubated with Schisantherin A for 1 h and then stimulated with 1 mg/L LPS for 12 h. Both LPS and samples are untreated in control group. After the cell culture media are collected, nitrite and PGE2 levels are determined, and Schisantherin A is found to reduce NO and PGE2 production in a dose-dependent manner.
Read more...

Storage & Handling

−
StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
Schisantherin A | Gomisin C

Similar Products

−
  • Schisantherin S

    Schisantherin S [orb1943574]

    2230512-49-7

    430.49

    C24H30O7

    5 mg, 50 mg
  • Schisantherin A

    Schisantherin A [orb1304851]

    99.99%

    58546-56-8

    536.57

    C30H32O9

    1 ml x 10 mM (in DMSO), 100 mg, 50 mg, 25 mg, 10 mg
  • Schisantherin E

    Schisantherin E [orb1690891]

    99.91% (May vary between batches)

    64917-83-5

    538.59

    C30H34O9

    1 ml x 10 mM (in DMSO), 10 mg, 5 mg, 1 mg
  • Schisantherin B

    Schisantherin B [orb1300178]

    99.06% (May vary between batches)

    58546-55-7

    514.56

    C28H34O9

    5 mg, 10 mg, 50 mg, 25 mg, 100 mg, 1 ml x 10 mM (in DMSO), 2 mg
  • Schisantherin D

    Schisantherin D [orb1684234]

    64917-82-4

    520.534

    C29H28O9

    5 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol
Others

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Find More Protocols

Schisantherin A (orb1222003)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Login to review

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 g
Enquire
100 mg
Enquire
200 mg
Enquire
500 mg
Enquire
5 mg
$ 120.00
10 mg
$ 160.00
25 mg
$ 300.00
50 mg
$ 420.00
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

info@biorbyt.com

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor