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Setipiprant

SKU: orb1304123

Description

Setipiprant is a potent and selective CRTH2 antagonist (IC50: 6.0 nM) that blocks the PGD2-mediated chemotaxis and activation of Th2 cells, eosinophils, and basophils. It is widely used in preclinical research to investigate allergic asthma and other inflammatory diseases, with applications in both in vitro cellular assays and in vivo animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number866460-33-5
MW402.42
Purity99.16%
FormulaC24H19FN2O3
SMILESC(C(O)=O)N1C2=C(C=3C1=CC=C(F)C3)CN(C(=O)C=4C5=C(C=CC4)C=CC=C5)CC2
TargetGPCR,Prostaglandin Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.97 mM);DMSO:45 mg/mL (111.82 mM)

Bioactivity

Target IC50
DP1 (human):1290 nM|CRTH2:6.0 nM|EP2:2600 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CRTh2, dog, asthma, cAMP, calcium liberation, ACT 129968, ACT129968, ACT-129968, KYTH 105, KYTH105, KYTH-105, inhibit, oral, Inhibitor, HEK-293, rhinitis, ProstaglandinReceptor, Prostaglandin Receptor, Setipiprant, selective, rat

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Quality Guarantee

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Key Properties

No computed properties available.

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Setipiprant (orb1304123)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 70.00
25 mg
$ 90.00
50 mg
$ 120.00
100 mg
$ 170.00
200 mg
$ 320.00
DispatchUsually dispatched within 3-5 working days
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