SHH (C1) Antibody, Rabbit Polyclonal

SKU: orb66794

Description

Rabbit polyclonal to SHH.Sonic hedgehog (SHH) protein is instrumental in the development of all known animals. In theembryo, it is the key signal in patterning of the ventral neural tube, the anterior-posterior limb axis, andthe ventral somites. In the adult it controls stem cell proliferation. It binds to the patched (PTC)receptor, which functions in association with smoothened (SMO) to activate the transcription of genes.Disruption in SHH signaling during development either through defects in the protein, or maternalteratogen consumption can lead to developmental disorders such as holoprosencephaly (HPE).Abberant activation of the SHH signaling pathway is associated with several types of cancer.

Research Area

Developmental Biology, Epigenetics

Images & Validation

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Item 1 of 1

Tested Applications	WB
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal region of human SHH
Molecular Weight	50
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-SHH antibody,anti-HHG1 antibody,anti-HLP3 antibody,anti-HPE3 antibody,anti-MCOPCB5 antibody,anti-SMMCI antibody,anti-TPT antibody,anti-TPTPS antibody

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Western blot analysis of total cell extracts from mouse liver using SHH antibody

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UniProt

Q15465

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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