Sivelestat sodium tetrahydrate

SKU: orb1705435

Description

Sivelestat sodium tetrahydrate (ONO-5046) is a potent and competitive inhibitor of human neutrophil elastase, exhibiting an IC50 of 44 nM and a Ki of 200 nM. This compound is a research tool for investigating conditions such as acute lung injury and ARDS, including in the context of COVID-19, with applications in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	201677-61-4
MW	528.51
Purity	99.68% (May vary between batches)
Formula	C₂₀H₂₉N₂NaO₁₁S
SMILES	O.O.O.O.[NaH].CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O
Target	SARS-CoV,Serine Protease
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.46 mM);DMSO:225 mg/mL (425.73 mM)

Bioactivity

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In Vivo

Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamsters (ID50 = 82 pg/kg) and increases skin capillary permeability in guinea pigs (ID50 = 9.6 mg/kg) via intravenous administration, both induced by human neutrophil elastase. Additionally, Sivelestat (10 mg/kg, tail vein infusion) ameliorates lung injury after hemorrhagic shock in rats, and prevents ischemia-reperfusion injury in the rat bladder (15, 60 mg/kg, ip).

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Elaspol, Elaspol sodium, Elaspol sodium tetrahydrate, Elaspol sodium Tetrahydrate, ONO 5046, ONO5046 sodium, ONO-5046 sodium, ONO5046 sodium tetrahydrate, ONO5046 sodium Tetrahydrate, ONO-5046 sodium tetrahydrate, ONO-5046 sodium Tetrahydrate, ONO5046, ONO-5046, Neutrophil elastase (human), Serine Protease, SerineProtease, Sivelestat Sodium, Sivelestat sodium, Sivelestat Sodium Hydrate, Sivelestat sodium Tetrahydrate

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Compound Identifiers

PubChem CID

173042247 ↗

Key Properties

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No computed properties available.

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