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SKF-86002

SKU: orb1305588

Description

SKF-86002 is a potent and cell-permeable p38 MAP kinase inhibitor with an IC50 of 0.5-1 µM. It effectively suppresses LPS-induced production of pro-inflammatory cytokines IL-1 and TNF-α in human monocytes. This compound is a valuable tool for investigating p38 signaling in inflammatory disease models, both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number72873-74-6
MW297.35
Purity99.85% (May vary between batches)
FormulaC16H12FN3S
SMILESFc1ccc(cc1)-c1nc2SCCn2c1-c1ccncc1
Targetp38 MAPK,TNF
SolubilityDMSO:Slightly soluble

Bioactivity

Target IC50
TNF-α:1 μM|IL-1:1 μM|p38 MAPk:0.5-1 μM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

lipoxygenase, inhibit, p38 MAPK, p38MAPK, metabolism, Inhibitor, cyclooxygenase, 5-lipoxygenase, acid, anti-arthritic, anti-inflammatory, analgesic, arachidonic, SKF86002, SKF-86002, SKF 86002, TNF-α

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Key Properties

No computed properties available.

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SKF-86002 (orb1305588)

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% DMSO +
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% Tween 80 +
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Available Sizes

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5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 140.00
50 mg
$ 190.00
100 mg
$ 260.00
200 mg
$ 350.00
DispatchUsually dispatched within 3-5 working days
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