SN 2

SKU: orb1309082

Description

SN 2 is a potent and selective TRPML3 channel activator (EC50 = 1.13 µM). This small molecule also exhibits antiviral activity against dengue virus (DENV2) and Zika virus (ZIKV) in vitro, making it a useful research tool for studying lysosomal function and host-pathogen interactions.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	823218-99-1
MW	255.35
Purity	99.86% (May vary between batches)
Formula	C₁₇H₂₁NO
SMILES	Cc1cc(C)c(C2=NOC3C4CCC(C4)C23)c(C)c1
Target	TRP/TRPV Channel,Anti-infection
Solubility	DMSO:16.67 mg/mL (65.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.83 mM)

Bioactivity

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Target IC50

TRPML3:1.13 μM(EC50)|TRPML1: >29.9 μM

In Vitro

When activated with 10 μM SN-2, at -80 mV, the conductance of the TRPML3 channel is approximately 10 pS. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone.SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at 80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K).

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, SN 2, SN2, SN-2, Transient receptor potential channels, TRPVChannel, TRPML1, TRPML3, TRPV Channel, TRPChannel, TRP Channel

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Compound Identifiers

PubChem CID

11834987 ↗

Key Properties

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No computed properties available.

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SN 2 (orb1309082)

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Applications:	ELISA, IF, IHC
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IHC-P, WB
Predicted Reactivity:	Porcine
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IHC, IHC-P, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Purity:	0.98
MW:	3449.38
Formula:	C₁₆₆H₃₁₉O₆₃N₉

Applications:	ELISA, WB
Predicted Reactivity:	Canine, Porcine
Reactivity:	Human
Species/Host:	Goat
Clonality:	Polyclonal
Conjugation:	Unconjugated

SN 2

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Key Properties

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Protocol Information

SN 2 (orb1309082)

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