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Sofalcone

SKU: orb1302400

Description

Sofalcone

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number64506-49-6
MW450.52
Purity99.40%
FormulaC27H30O6
SMILESO(CC(O)=O)C1=C(C(C=CC2=CC=C(OCC=C(C)C)C=C2)=O)C=CC(OCC=C(C)C)=C1
TargetAutophagy,Antibacterial
SolubilityDMSO:50 mg/mL (110.98 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.55 mM)

Bioactivity

In Vitro
Sofalcone (50 μmol/L) significantly enhances HO-1 mRNA and protein expression in both trophoblasts and primary human umbilical vein endothelial cells (HUVECs), evidenced by Western blot analyses and comparison with control groups (P<0.05). It also boosts Nrf2 presence in HUVEC nuclear fractions after 6 hours and upregulates NQO1, TXN, and GCLC expression in primary HUVECs dose-dependently over 24 hours. Additionally, Sofalcone markedly reduces sFlt-1 concentrations in culture media and decreases THP-1 monocyte adherence to HUVECs in a dose-dependent manner, underscoring its potential therapeutic implications for vascular health.
Cell Research
Primary HUVECs are seeded at 60 000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, Autophagy, Bacterial, (HO)-1, SU 88, SU88, SU-88, Sofalcone

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Quality Guarantee

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Key Properties

No computed properties available.

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Sofalcone (orb1302400)

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% DMSO +
%+
% Tween 80 +
%

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50 mg
$ 80.00
100 mg
$ 90.00
500 mg
$ 130.00
1 g
$ 160.00
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