SP 600125, negative control

SKU: orb1692168

Description

SP 600125 negative control is a methylated analog serving as a negative control for the JNK inhibitor SP 600125. It inhibits the DTP3 and GADD45β/MKK7 complex, restoring pathway activation, and exhibits IC50 values of 18 μM and 24 μM against JNK2 and JNK3, respectively. This compound is a valuable tool for validating JNK-related signaling mechanisms in both cellular and biochemical assays.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	54642-23-8
MW	234.25
Purity	99.89% (May vary between batches)
Formula	C₁₅H₁₀N₂O
SMILES	O=C1C=2C=3C(C=4C1=CC=CC4)=NN(C)C3C=CC2
Target	JNK,Others,Ferroptosis,Apoptosis,Autophagy
Solubility	DMSO:9 mg/mL (38.42 mM)

Bioactivity

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Target IC50	TrkB:0.899 µM

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GADD45β/MKK7, JNK3, JNK Inhibitor II, negative control, JNK2, SP 600125, negative control

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Compound Identifiers

PubChem CID

11665831 ↗

Key Properties

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No computed properties available.

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