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SP187

SKU: orb1706613

Description

SP187 (MON-DNJ) is a host-targeted iminosugar with broad-spectrum antiviral research applications. It has demonstrated inhibitory activity against filoviruses, influenza, and dengue viruses in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number615253-61-7
MW319.44
Purity99.87% (May vary between batches)
FormulaC16H33NO5
SMILESCOCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
TargetInfluenza Virus,Virus Protease,Anti-infection
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.26 mM);DMSO:63.89 mg/mL (200.01 mM)

Bioactivity

Target IC50
EBOV:29.97 μM|MARV:47.72 μM
In Vivo
In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12-hour intervals for UV-5 or TID at approximately 8-hour intervals for SP187. The selected doses and schedules are based on tolerability studies in naïve mice. No efficacy is observed in the iminosugar-treated mice as compared to the vehicle control.
In Vitro
SP187 (UV-4) is evaluated in vitro for its antiviral efficacy against EBOV and MARV using a yield-plaque assay format. SP187 demonstrates antiviral activity with IC50 values of 29.97 μM and 47.72 μM against EBOV and MARV, respectively.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SP187, SP-187, SP 187, UV 4, UV4, UV-4, VirusProtease, Virus Protease, Dengue Fever virus, EBOV, Filovirus, MARV, MON-​DNJ, MON-DNJ, InfluenzaVirus, Influenza virus, Influenza Virus
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Key Properties

No computed properties available.

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Protocol Information

SP187 (orb1706613)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 160.00
5 mg
$ 210.00
10 mg
$ 300.00
25 mg
$ 440.00
50 mg
$ 580.00
100 mg
$ 740.00
200 mg
$ 990.00
DispatchUsually dispatched within 3-5 working days
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