(S,R,S)-AHPC-Boc derivative 1

SKU: orb3028342

Description

(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2086298-33-9
MW	560.705
Formula	C₂₈H₄₀N₄O₆S
SMILES	C([C@@H](NC(OC(C)(C)C)=O)C(C)(C)C)(=O)N1[C@H](C(N[C@@H](CO)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Target	MALT

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

MALT

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