Sulfosuccinimidyl oleate sodium

SKU: orb1309050

Description

Sulfosuccinimidyl oleate sodium is a cell-permeable long-chain fatty acid ester that irreversibly inhibits mitochondrial respiration and cellular fatty acid uptake. Its non-cytotoxic anti-inflammatory properties make it a valuable research tool for studying metabolism and inflammation in both cellular and animal models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	1212012-37-7
MW	481.58
Purity	>99.99% (May vary between batches)
Formula	C₂₂H₃₆NNaO₇S
SMILES	CCCCCCCC/C=C\CCCCCCCC(ON1C(C(S(=O)([O-])=O)CC1=O)=O)=O.[Na+]
Target	Others,Mitophagy
Solubility	DMSO:70 mg/mL (145.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.15 mM)

Bioactivity

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Target IC50	mitoCHO cellsndrial respiratory chain:4 μM
In Vivo	METHODS: Sulfosuccinimidyl oleate sodium (50 mg/kg, oral) was treated in pMCAo mice and its therapeutic effect was tested; mice were analyzed for ischemia-induced cerebral microgliosis by immunohistochemical staining against Iba-1 3 days after stroke. RESULTS Sulfosuccinimidyl oleate sodium significantly reduced the size of cortical ischemic infarcts, and significantly upregulated microgliosis was detected in the peri-ischemic area of sulfosuccinimidyl oleate sodium-treated mice 3 days after stroke. A significant decrease in the degree of Iba-1 immunoreactivity was observed in the peri-ischemic area. Read more...
In Vitro	METHODS: BV2 cells were treated with Sulfosuccinimidyl oleate sodium (50μM) and exposed to 100 ng/ml LPS and 5 ng/ml IFNγ. The mRNA expression levels of IL-6, NOS2, Nrf2 and HO-1 were detected by qRT-PCR; WB detects the expression of NOS2, COX-2, HO-1, p-p38, t-p38 and β-actin in cells. RESULTS Combined treatment with Sulfosuccinimidyl oleate sodium blocked the increase in the expression levels of IL-6 and NOS2; co-treatment with SSO allowed LPS + IFNγ to reduce the Nrf2 expression level back to the basal level; combined treatment with Sulfosuccinimidyl oleate sodium significantly reduced the expression level of Nrf2. Expression of NOS2 and COX-2 in BV2 cells induced by LPS + IFNγ; Sulfosuccinimidyl oleate sodium alone increased the basal protein level of HO-1, but did not change the level of HO-1 induced by LPS + IFNγ. Read more...

Storage & Handling

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Storage	keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Sulfo-N-succinimidyl oleate sodium, Sulfosuccinimidyl oleate sodium

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Compound Identifiers

PubChem CID

90469841 ↗

Key Properties

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No computed properties available.

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