Suplatast tosilate

SKU: orb1223578

Description

A Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production; suppresses IgE production, eosinophil infiltration and histamine release; exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.Allergy Approved(In Vitro):IPD-1151T (1-10 μM; 10 d) induces a concentration-dependent suppression of purified allergen (Cry j 1)-dependent IgE synthesis in autologous B cell cultures mediated by SN-4, without significantly affecting the IgG synthesis.IPD-1151T (1-10 μM; 24 h) clearly depresses phytohemagglutinin (PHA)-induced expression of IL-4 mRNA in normal peripheral blood mononuclear cells (PBMC).(In Vivo):Suplatast Tosilate (100 mg/kg; once daily for 21 d) inhibits the production of Th2 cytokines, which inhibits eosinophil infiltration into the murine airway, IgE synthesis, and development of BHR, in a murine model of asthma.Suplatast Tosilate (100 μg/kg; once daily for 14 d) strongly suppresses immunoglobulin E contents in serum.

Images & Validation

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Key Properties

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CAS Number	94055-76-2
MW	499.6406
Purity	>98% (HPLC)
Formula	C₂₃H₃₃NO₇S₂
SMILES	CCOCC(O)COC1=CC=C(NC(=O)CC[S+](C)C)C=C1
Target	IL Receptor
Solubility	DMSO: ≥ 33 mg/mL

Bioactivity

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In Vivo

Suplatast Tosilate (100 mg/kg; once daily for 21 d) inhibits the production of Th2 cytokines, which inhibits eosinophil infiltration into the murine airway, IgE synthesis, and development of BHR, in a murine model of asthma. Suplatast Tosilate (100 μg/kg; once daily for 14 d) strongly suppresses immunoglobulin E contents in serum. Animal model: Female BALB/c mice (6-8 weeks old) are immunized with ovalbumin. Dosage: 100 mg/kg. Administration: p.o. once a day for 21 days. Result: Reduced the number of total cells and eosinophils. Almost completely inhibited the development of antigen-induced bronchial hyperresponsiveness (BHR). Decreased the levels of IL-4, IL-5 and IL-13.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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IPD-1151T

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IL Receptor

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