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Talampanel

SKU: orb1307705

Description

Talampanel (LY-300164) is a selective, orally active AMPA receptor antagonist with demonstrated anti-seizure activity. It has shown neuroprotective efficacy in preclinical rodent models of stroke and is used in research targeting epilepsy and neurodegenerative conditions.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number161832-65-1
MW337.37
Purity98.30% (May vary between batches)
FormulaC19H19N3O3
SMILESC[C@@H]1Cc2cc3OCOc3cc2C(=NN1C(C)=O)c1ccc(N)cc1
TargetApoptosis,GluR,iGluR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.86 mM);DMSO:100 mg/mL (296.41 mM)

Bioactivity

In Vivo
Talampanel (p.o.; 5 mg/kg; once a day; 2 weeks) decreases motoneuronal calcium in a mouse model of ALS .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Talampanel, inhibit, Ionotropic glutamate receptors, LY300164, LY-300164, LY 300164, iGluR, Inhibitor, GYKI 53773, GYKI53773, GYKI-53773, AMPA, Apoptosis
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Key Properties

No computed properties available.

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Protocol Information

Talampanel (orb1307705)

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% DMSO +
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% Tween 80 +
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Available Sizes

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2 mg
$ 80.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 190.00
50 mg
$ 290.00
DispatchUsually dispatched within 3-5 working days
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