TC-MCH 7c

SKU: orb1708402

Description

TC-MCH 7c is a phenylpyridone-derived, orally bioavailable and brain-penetrant antagonist of the melanin-concentrating hormone receptor 1 (MCH1R). It exhibits high affinity with Ki values of 3.4 nM for human and 3.0 nM for mouse MCH1R, making it a valuable tool for investigating MCH1R function in both in vitro assays and in vivo models of energy homeostasis and mood regulation.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	864756-35-4
MW	408.47
Purity	99.54%
Formula	C₂₄H₂₅FN₂O₃
SMILES	Fc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1
Target	Melanin-concentrating Hormone Receptor (MCHR),GPCR
Solubility	DMSO:55 mg/mL (134.65 mM)

Bioactivity

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Target IC50	MCH1R (human):(ki)3.4 nM \|MCH1R (human):5.6 nM \|MCH1R (human):5.6 nM\|MCH1R (human):3.4 nM (ki)\|MCH1R (mouse):3.0 nM \|MCH1R (mouse):3.0 nM
In Vivo	In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner . TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively. Read more...
In Vitro	In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R . TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MCH1-R, MCHR, Melanin-concentrating Hormone Receptor, Melaninconcentrating Hormone Receptor (MCHR), MelaninconcentratingHormoneReceptor, MelaninconcentratingHormoneReceptor(MCHR), mouse MCH1R, hMCH1R, TCMCH 7c, TC-MCH 7c, TC MCH 7c

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Compound Identifiers

PubChem CID

11654412 ↗

Key Properties

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No computed properties available.

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TC-MCH 7c (orb1708402)

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TC-MCH 7c

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

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Protocol Information

TC-MCH 7c (orb1708402)

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