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Tebufenpyrad

SKU: orb1302852

Description

Tebufenpyrad

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number119168-77-3
MW333.86
Purity98.92%
FormulaC18H24ClN3O
SMILESCCc1nn(C)c(C(=O)NCc2ccc(cc2)C(C)(C)C)c1Cl
TargetMitochondrial Metabolism
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.99 mM);DMSO:60 mg/mL (179.72 mM)

Bioactivity

In Vitro
Exposing rat dopaminergic neuronal cells (N27 cells) to tebufenpyrad and pyridaben for 3 h induced dose-dependent cell death with an EC50 of 3.98 μM and 3.77 μM, respectively Also, tebufenpyrad and pyridaben (3 μM) exposure induced Reactive oxygen species (ROS) generation and m-aconitase damage, suggesting tha the pesticide toxicity is associated with oxidative damage. Morphometric image analysis wit the MitoTracker red fluorescent probe indicated that tebufenpyrad and pyridaben, as well as rotenone, caused abnormalities in mitochondrial morphology, including reduced mitochondrial length and circularity. Functional bioenergetic experiments usin the Seahorse XF96 analyzer revealed that tebufenpyrad and pyridaben very rapidly suppresse the basal mitochondrial oxygen consumption rate similar to that of rotenone. Further analysis of bioenergetic curves also revealed dose-dependent decreases in ATP-linked respiration and respiratory capacity the luminescence-based ATP measurement further confirmed that pesticide-induced mitochondrial Inhibition of respiration is accompanied b the loss of cellular ATP.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Comanche, mitochondrial complex-1, Mitochondrial Metabolism, MitochondrialMetabolism, MK 239, MK239, MK-239, Pyranica, Tebufenpyrad

Similar Products

  • Tebufenpyrad [orb1222825]

    >98% (HPLC)

    119168-77-3

    333.9

    C18H24ClN3O

    1 g, 500 mg, 200 mg, 100 mg
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Key Properties

No computed properties available.

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Tebufenpyrad (orb1302852)

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% DMSO +
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% Tween 80 +
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25 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
50 mg
$ 100.00
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