Telaprevir

SKU: orb1300995

Description

Telaprevir

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	402957-28-2
MW	679.85
Purity	98.89%
Formula	C₃₆H₅₃N₇O₆
SMILES	CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C1CCCCC1)C(C)(C)C)C(=O)C(=O)NC1CC1
Target	HCV Protease,SARS-CoV
Solubility	Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:125 mg/mL (183.86 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:3.3 mg/mL (4.85 mM)

Bioactivity

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Target IC50	HCV NS3/4A serine protease:0.35 μM
In Vivo	Telaprevir (17.5 μM) effectively eradicates HCV RNA in replicating cells, with no recurrence observed 13 days post-treatment. When used in combination with IFN-α, Telaprevir moderately enhances the synergistic effect, reducing HCV RNA replication and inhibiting resistance mutations without significant toxicity. The compound exhibits a time-dependent increase in inhibitory efficacy against HCV RNA replication, with IC50 values of 0.574 μM, 0.488 μM, 0.210 μM, and 0.139 μM at 24, 48, 72, and 120 hours, respectively. In Con1 (genotype 1b) subgenomic HCV replicon cells, Telaprevir inhibits the HCV NS3-4A serine protease, suppressing viral polyprotein processing and consequently diminishing all HCV RNA and protein levels in a time and dose-dependent manner. Additionally, Telaprevir shows no toxicity in HCV replicating cells or parent Huh-7 and HepG2 cells after 48 hours of treatment. Read more...
In Vitro	In a mouse model, Telaprevir administration at doses of 10 and 25 mg/kg (p.o.) reduced hepatitis C virus protease-dependent cleavage (18.7%) and secretion of SEAP (18.4%) from the liver to the bloodstream. In mice with genotype 1b HCV-infected human hepatocytes, a one-week treatment with Telaprevir at 200 mg/kg resulted in a decrease in HCV RNA levels. Furthermore, when used in combination with MK-0608 at a dose of 50 mg/kg over four weeks, this regimen completely eliminated the virus from the mice. Read more...
Cell Research	Cells are incubated with various concentrations of Telaprevir for 48 hours. Cell viability is determined by using a tetrazolium (MTS)-based cell viability assay.(Only for Reference) Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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HCVProtease, HCV Protease, HCV NS3-4A serine protease, HCV, Hepatitis C virus, Incivek, MP424, MP-424, MP 424, inhibit, Inhibitor, LY 570310, LY570310, LY-570310, VX950, VX-950, SARSCoV, SARS-CoV, SARS coronavirus, Telaprevir, VX 950

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Compound Identifiers

PubChem CID

3010818 ↗

Key Properties

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No computed properties available.

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CAS Number:	944716-73-8
MW:	222.71
Formula:	C₉H₁₉ClN₂O₂

Purity:	>98% (HPLC)
CAS Number:	402957-28-2
MW:	679.8
Formula:	C₃₆H₅₃N₇O₆

Telaprevir

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Telaprevir (orb1300995)

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