Teplizumab Antibody

SKU: orb1980680

Description

Teplizumab (MGA-031) is a humanized anti-CD3 monoclonal antibody developed to delay the progression of type 1 diabetes by preserving pancreatic beta cell function. It is utilized in research to investigate immunomodulation, both in vitro and in animal models of autoimmune diabetes.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	876387-05-2
MW	145.79 kDa
Purity	99.7% (SEC-HPLC)
Target	Integrin,Others

Bioactivity

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In Vivo	In NSG mice, Teplizumab (0.24 mg/kg, i.p.) induces migration of human CD4 T cells to the lamina propria and ablates the treatment effects of the drug on graft survival. Read more...
In Vitro	Teplizumab induces human CD8+ T-cell proliferation (10 ng/mL-10 μg/mL, 5 days). Teplizumab increases the expression of CD25 and intracellular CTLA4 on CD8+ cells (freshly isolated PBMCs) after 6 days. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MGA-031, CD3, PRV-031

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Gene Symbol

Integrin,Others

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