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Tiamulin fumarate

SKU: orb1909127

Description

Tiamulin fumarate is a semisynthetic diterpenoid antibiotic that inhibits bacterial protein synthesis. It is widely used in research applications, including in vitro and in vivo studies of pathogens like Pneumocystis and swine dysentery-causing bacteria.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number55297-96-6
MW609.81
Purity99.64% (May vary between batches)
FormulaC32H51NO8S
SMILESOC(=O)\C=C\C(O)=O.[H][C@@]12C(=O)CC[C@]11CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CSCCN(CC)CC
TargetAntibacterial,Antibiotic
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.41 mM);H2O:80 mg/mL (131.19 mM);DMSO:250 mg/mL (409.96 mM)

Bioactivity

In Vivo
Tiamulin is highly effective in treating swine dysentery in both breeding and laying hens, with significant efficacy against B. pilosicoli and B. intermedia at a dose of 25 mg/kg body weight per day for 5 consecutive days .
In Vitro
Tiamulin exhibits high activity against mycoplasma strains (Gloss M. gallisepticum, M. synoviae, M. meleagridis, and M. iowae), spirochetes (Brachyspira hyodysenteriae, Brachyspira innocens, B. pilosicoli, B. intermedia), and Gram-positive bacteria (Staphylococcus, Streptococcus, Clostridium, and Campylobacter spp), but its activity against Gram-negative bacteria (Bordetella, Klebsiella, Haemophilus, Clostridium, Campylobacter, and Corynebacterium spp) is relatively low.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Thiamutilin fumarate, Tiamulin fumarate, Antibacterial

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Key Properties

No computed properties available.

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Protocol Information

Tiamulin fumarate (orb1909127)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
100 mg
$ 80.00
500 mg
$ 120.00
1 g
$ 150.00