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Tideglusib

SKU: orb1304574

Description

Tideglusib (NP031112) is a non-ATP competitive GSK-3 inhibitor exhibiting neuroprotective and anti-inflammatory properties. It has been investigated in preclinical models for neurodegenerative diseases, including Alzheimer's disease, demonstrating therapeutic potential in both in vitro and in vivo experimental studies.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number865854-05-3
MW334.39
Purity99.84% (May vary between batches)
FormulaC19H14N2O2S
SMILESO=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1
TargetGSK-3
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.98 mM);Ethanol:15 mg/mL (44.9 mM)

Bioactivity

Target IC50
GSK-3β:60 nM|GSK-3β (WT):5 nM
In Vivo
Tideglusib (2.5 μM) inhibited glutamate-induced cell activation in rat primary astrocytes or microglia. In human adult neuroblastoma cells and murine primary neurons, Tideglusib irreversibly inhibited GSK-3, resulting in a decrease in tau protein phosphorylation levels and preventing apoptosis.
In Vitro
Tideglusib (2.5 μM) inhibited glutamate-induced cell activation in rat primary astrocytes or microglia. In human adult neuroblastoma cells and murine primary neurons, Tideglusib irreversibly inhibited GSK-3, resulting in a decrease in tau protein phosphorylation levels and preventing apoptosis.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSK-3β, GSK-3, GSK3, Glycogen synthase kinase 3, Glycogen synthase kinase-3, Inhibitor, inhibit, NP 031112, NP 12, NP031112, NP-031112, NP12, NP-12, Tideglusib

Similar Products

  • Tideglusib [orb1223812]

    >98% (HPLC)

    865854-05-3

    334.39

    C19H14N2O2S

    25 mg, 100 mg, 200 mg, 10 mg, 50 mg, 500 mg, 1 g
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Key Properties

No computed properties available.

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Protocol Information

Tideglusib (orb1304574)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

10 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 110.00
50 mg
$ 160.00
100 mg
$ 240.00
200 mg
$ 340.00
500 mg
$ 560.00
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