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TLR3-IN-1

SKU: orb1305845

Description

TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor with an IC50 of 3.44 μM. It blocks dsRNA-induced TLR3 signaling and reduces pro-inflammatory cytokine production, such as TNF-α and IL-1β, in cellular models like RAW 264.7 macrophages, supporting its use in studying innate immunity and inflammatory diseases.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1279713-77-7
MW377.82
Purity98.56%
FormulaC18H13ClFNO3S
SMILESOC(=O)[C@@H](Cc1ccccc1)NC(=O)c1sc2cc(F)ccc2c1Cl
TargetTLR
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.62 mM);DMSO:250 mg/mL (661.69 mM)

Bioactivity

Target IC50
TLR3:3.44 μM (in RAW 264.7 cells)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CU-CPT 4a, CU CPT 4a, Inhibitor, inhibit, IL-1β, TLR3 IN 1, TLR3/dsRNA complex, TLR3IN1, TLR-3-IN-1, TLR3-IN-1, TLR3, Toll-like Receptor (TLR), TNF-α, protein-RNA interaction
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

TLR3-IN-1 (orb1305845)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 230.00
25 mg
$ 440.00
50 mg
$ 640.00
100 mg
$ 890.00
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