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TMN355

SKU: orb1309004

Description

TMN355 is a potent and selective cyclophilin A inhibitor. It has been shown to suppress foam cell formation and pro-inflammatory cytokine secretion in cellular models of atherosclerosis, indicating its utility for cardiovascular disease research.

Images & Validation

Key Properties

CAS Number1186372-20-2
MW380.8
Purity99.15%
FormulaC21H14ClFN2O2
SMILESFc1cccc(Cl)c1C(=O)NC(=O)NC1c2ccccc2-c2ccccc12
TargetOthers
Solubility10% DMSO+90% Corn Oil:2 mg/mL (5.25 mM);DMSO:40 mg/mL (105.04 mM)

Bioactivity

In Vitro
Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL. The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p < 0.0001). Levels of extracellular cyclophilin A and other inflammatory cytokines such as TNF-α and MCP-1also significantly reduced. TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And cyclophilin A after 6 h of activation inhibited by TMN 355(1 μM).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, cyclophilin A, TMN 355, TMN-355, TMN355

Similar Products

  • TMN355 [orb1219292]

    >98% (HPLC)

    1186372-20-2

    380.8

    C21H14ClFN2O2

    1 g, 25 mg, 50 mg, 100 mg, 500 mg, 5 mg, 10 mg
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Key Properties

No computed properties available.

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TMN355 (orb1309004)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 130.00
5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 290.00
50 mg
$ 420.00
100 mg
$ 590.00
500 mg
$ 1,210.00
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