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Tolnaftate

SKU: orb1225550

Description

Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.(In Vitro):Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.

Images & Validation

Key Properties

CAS Number2398-96-1
MW307.42
Purity>98% (HPLC)
FormulaC19H17NOS
SMILESS=C(OC1=CC=C2C=CC=CC2=C1)N(C)C3=CC=CC(C)=C3
TargetHedgehog (Hh)
SolubilityDMSO: 62 mg/mL (201.68 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NSC 233648 | SCH 10144

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Tolnaftate (orb1225550)

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1 g
$ 100.00
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