Torachrysone-8-O-b-D-glucoside

SKU: orb1297186

Description

Torachrysone-8-O-β-D-glucoside is a bioactive compound that acts as an alpha-glucosidase inhibitor. This mechanism supports its investigation for type 2 diabetes management in biochemical and pharmacological research, including in vitro enzyme inhibition studies.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	64032-49-1
MW	408.4
Purity	99.98%
Formula	C₂₀H₂₄O₉
SMILES	COc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c(C(C)=O)c(C)cc2c1
Target	Antifection
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.45 mM);DMSO:65 mg/mL (159.16 mM)

Bioactivity

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In Vitro

A new kind of in vitro α±-glucosidase inhibition assay based on using maltose as the substrate was developed, and this new established method was used to determine the α±-glucosidase inhibitory activities of Polygonum multiflorum and four anthraquinone compounds. As a result, Polygonum multiflorum showed 50% α±-glucosidase inhibition at the concentration of 0.0032 mg mL-1 and four anthraquinone compounds including emodin, aloe-emodin, physcion and rhein showed strong α±-glucosidase inhibitory activities with IC50 values ranging from 4.12 μM to 5.68 μM, respectively. Moreover, the centrifugal ultrafiltration with LC-ESI-MSn was used to screen and identify active α±-glucosidase inhibitors from Polygonum multiflorum extract and nine small-molecule active compounds were successfully identified as potential α±-glucosidase inhibitors.

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Antifection, Inhibitor, inhibit, Torachrysone 8 O b D glucoside, Torachrysone 8-O-glucoside, Torachrysone8ObDglucoside, Torachrysone-8-O-b-D-glucoside

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Compound Identifiers

PubChem CID

11972479 ↗

Key Properties

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No computed properties available.

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