trans-AUCB

SKU: orb1307651

Description

trans-AUCB (t-AUCB) is a potent and selective soluble epoxide hydrolase (sEH) inhibitor, demonstrating low nanomolar IC50 values against human, mouse, and rat enzymes. It is widely used in research to investigate the role of sEH in cardiovascular, inflammatory, and neuropathic pain models, both in vitro and in vivo.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	885012-33-9
MW	412.52
Purity	99.66% (May vary between batches)
Formula	C₂₄H₃₂N₂O₄
SMILES	OC(=O)c1ccc(OC2CCC(CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1
Target	Epoxide Hydrolase
Solubility	DMSO:100 mg/mL (242.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.7 mM)

Bioactivity

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Target IC50	sEH:1.3 Nm(human)\|sEH:8 nM (mouse)\|sEH:8 nM (rat)
In Vivo	trans-AUCB (i.v.; 0.1 mg/kg) has t1/2 values of 70 min and 10 hours for distribution (α) and elimination (β) phases. trans-AUCB has a CL of 0.7 L/h kg and a Vdss was 17 L/kg. trans-AUCB (p.o.; 0.1, 0.5, 1 mg/kg) has t1/2 values of 20, 30, 15 min. trans-AUCB (p.o. of 0.1, 0.5, 1 mg/kg) shows Cmax values of 30, 100, 150 nmol/L. trans-AUCB (t-AUCB; p.o.; 0.1, 0.5, 1 mg/kg) ameliorates the LPS-induced hypotension in a dose-dependent manner. trans-AUCB (s.c.; 1, 3, 10 mg/kg) has t1/2 values of 60, 85, 75 min. trans-AUCB(s.c. of 1, 3, 10 mg/kg) has Cmax values of 245, 2700, 3600 nmol/L . Read more...
In Vitro	trans-AUCB (25-300 μM; 48 hours) inhibits U251 and U87 cell growth in a dose-dependent manner. trans-AUCB (200 μM; 48 hours) suppresses U251 and U87 cell growth by activating NF-jB-p65. trans-AUCB (10 μM; 30 min) efficiently suppresses sEH activities in human glioblastoma cell lines and human hepatocellular carcinoma cell lines. trans-AUCB (200 μM; 48 or 96 hours) induces cell-cycle G0/G1 phase arrest in U251 and U87 cells. trans-AUCB (200 μM; 10 min-4 hours) can increase the phosphorylation levels of p65 after 10 min, reaching to peak after 30 min and lasting for at least 2 hours . Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti-glioma, active, activity, EpoxideHydrolase, epoxide, Epoxide Hydrolase, hydrolase, hsEH, mouse sEH, Inhibitor, sEH, orally, inhibit, rat sEH, soluble, trans AUCB, t-AUCB, transAUCB, trans-AUCB

Quality Guarantee

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Compound Identifiers

PubChem CID

16038368 ↗

Key Properties

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No computed properties available.

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trans-AUCB (orb1307651)

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Purity:	>98% (HPLC)
CAS Number:	885012-33-9
MW:	412.5
Formula:	C₂₄H₃₂N₂O₄

trans-AUCB

Description

Research Area

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Key Properties

Bioactivity

Storage & Handling

Alternative Names

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