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TREK inhibitor-3

SKU: orb3029058

Description

TREK inhibitor-3 (Cpd8l) is a selective inhibitor of TREK-1 that can cross the blood-brain barrier, with an IC50 of 0.81 μM. It offers neuroprotective effects by significantly reducing cortical neuron death induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and alleviating brain injury in middle cerebral artery occlusion/reperfusion (MCAO/R) model mice. TREK inhibitor-3 is utilized in ischemic stroke research.

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Key Properties

CAS Number3023854-95-4
MW321.413
FormulaC21H23NO2
SMILESO=C1OC(C2=CC=C(C=C12)C3CCNCC3)CC=4C=CC=CC4C
TargetPotassium Channel

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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TREK inhibitor-3 (orb3029058)

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