TRX-0237 Methylate

SKU: orb1226700

Description

TRX-0237 Methylate (LMTX) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity; disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways; demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.Alzheimer Disease Phase 3 Clinical(In Vitro):Leucomethylene blue (100 nM, 48 h) mesylate not only decreases the tau and p-tau expression levels, but also reversed the promoting effects of Aβ25-35 on orexin A and adenosine A1R expression levels.

Images & Validation

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Key Properties

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CAS Number	1236208-20-0
MW	379.493
Purity	>98% (HPLC)
Formula	C₁₇H₂₁N₃O₃S₂
SMILES	CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
Target	Amyloids
Solubility	H2O : ≥ 31 mg/mL 64.91 mM

Bioactivity

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In Vitro	Western blot analysis. Cell line: Human SH-SY5Y cell line. Concentration: 100 nM. Incubation time: 48 h. Result: Aβ25-35 and TRx 0237 co-treatment significantly reversed the promoting effects of Aβ25-35 on tau, p-tau, orexin A and adenosine A1R expression. Read more...

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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LMTX | Hydromethylthionine | Methylene blue

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Gene Symbol

Amyloids

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