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U18666A

SKU: orb1307639

Description

U18666A is a cell-permeable small molecule that inhibits intracellular cholesterol synthesis and transport. This activity underlies its utility in research for suppressing the replication of viruses such as Ebola, Dengue, and HCV in vitro, making it a tool for studying lipid-dependent viral entry and pathogenesis.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number3039-71-2
MW424.06
Purity99.83% (May vary between batches)
FormulaC25H42ClNO2
SMILESCl.[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OCCN(CC)CC
TargetAnti-infection,HCV Protease
SolubilityDMSO:50 mg/mL (117.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.72 mM);H2O:10 mg/mL (23.58 mM)

Bioactivity

In Vitro
U18666A exhibits antiviral effects by impeding viral trafficking within cholesterol-laden late endosomes/lysosomes and inhibiting de novo sterol biosynthesis in infected cells. Additionally, an additive antiviral effect is observed when U18666A is combined with C75, a fatty acid synthase inhibitor .

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cholesterol transport, Cholesterol, inhibit, Inhibitor, Hepatitis C virus, HCVProtease, HCV, HCV Protease, U18666A, U-18666A

Similar Products

  • U18666A [orb1218191]

    >98% (HPLC)

    3039-71-2

    424.06

    C25H42ClNO2

    500 mg, 200 mg, 50 mg, 5 mg, 10 mg, 2 mg, 1 g, 25 mg, 100 mg
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Key Properties

No computed properties available.

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Protocol Information

U18666A (orb1307639)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 350.00
100 mg
$ 500.00
200 mg
$ 700.00
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