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UCB-5307

SKU: orb1688926

Description

UCB-5307 is a small molecule inhibitor of TNFR1 signaling that binds human TNFα with high affinity (K_D ~6-9 nM) via slow kinetics and can disrupt pre-formed TNF/TNFR1 complexes. Its utility in exploring TNF-driven pathology makes it a valuable tool for in vitro and in vivo inflammatory disease research.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1515887-44-1
MW343.42
Purity99.89% (May vary between batches)
FormulaC22H21N3O
SMILESCc1ccc(C)c(Cn2c(nc3ccccc23)C(O)c2ccncc2)c1
TargetTNF
SolubilityDMSO:65 mg/mL (189.27 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.82 mM)

Bioactivity

Target IC50
TNF-α:9 nM(KD)
In Vitro
UCB-5307 exhibits inhibition against wild-type TNF but does not inhibition against L57F TNF. The half-life of UCB-5307 is determined to be 3.3 hours. UCB-5307 disrupts a preexisting complex between hTNF and hTNFR1, penetrating the complex and displacing one of the receptors. Prior exposure of hTNF to UCB-5307 prevents one receptor from binding.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TNF-α

Similar Products

  • UCB-5307 [orb2900830]

    >98% (HPLC)

    1515887-44-1

    343.42

    C22H21N3O

    25 mg, 50 mg, 1 g, 100 mg, 500 mg, 2 mg, 5 mg, 10 mg
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Key Properties

No computed properties available.

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UCB-5307 (orb1688926)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 500.00
50 mg
$ 710.00
100 mg
$ 990.00
500 mg
$ 1,920.00
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