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Ustekinumab

SKU: orb1219987

Description

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

Images & Validation

Key Properties

CAS Number815610-63-0
MW148 kDa
Purity>98% (HPLC)
Formula——
TargetIL Receptor

Bioactivity

In Vitro
Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (KD) is calculated relative to Ustekinumab (Ustekinumab=1.0).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Ustekinumab (orb1219987)

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100 mg
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5 mg
$ 1,380.00
10 mg
$ 1,850.00
25 mg
$ 2,730.00
50 mg
$ 3,670.00