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Vacquinol-1

SKU: orb1745263

Description

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number5428-80-8
MW352.86
Purity99.92%
FormulaC21H21ClN2O
SMILESC(O)(C=1C2=C(N=C(C1)C3=CC=C(Cl)C=C3)C=CC=C2)C4CCCCN4
Targetp38 MAPK,JNK,Others
SolubilityEthanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:70 mg/mL (198.38 mM)

Bioactivity

In Vivo
In mice bearing U3013 mg tumors, Vacquinol-1 (15 μM intracranial injection, or 20 mg/kg p.o.) attenuates tumor growth and prolonging survival.
In Vitro
Vacquinol-1 induces rapid and specific cell death of glioma cells with IC50 of 3.14 μM via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture.
Cell Research
Cell viability is measured using CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer's instructions.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

activates MAPK pathways, glioblastoma multiforme, glioblastoma, Inhibitor, HCC, hepatocellular carcinoma, inhibit, induces apoptosis, NSC 13316, NSC13316, NSC-13316, MKK4, MKK4-specific activator, Vacquinol 1, Vacquinol1, Vacquinol-1

Similar Products

  • Vacquinol-1 [orb1224737]

    >98% (HPLC)

    5428-80-8

    352.9

    C21H21ClN2O

    1 g, 500 mg, 200 mg, 50 mg, 100 mg, 5 mg, 10 mg, 25 mg
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Key Properties

No computed properties available.

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Vacquinol-1 (orb1745263)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 240.00
5 mg
$ 470.00
10 mg
$ 680.00
25 mg
$ 1,030.00
50 mg
$ 1,400.00
100 mg
$ 1,870.00
DispatchUsually dispatched within 3-5 working days
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