Vardenafil

SKU: orb1710756

Description

Vardenafil (Vivanza) is a selective PDE5 inhibitor used for erectile dysfunction research. By blocking cGMP degradation, it enhances the nitric oxide-mediated signaling pathway crucial for penile smooth muscle relaxation. This mechanism is studied in both in vitro enzymatic assays and in vivo models of erectile function.

Research Area

Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	224785-90-4
MW	488.60
Purity	99.88% (May vary between batches)
Formula	C₂₃H₃₂N₆O₄S
SMILES	C(CC)C=1N2C(C(=O)N=C(N2)C3=C(OCC)C=CC(S(=O)(=O)N4CCN(CC)CC4)=C3)=C(C)N1
Target	Endogenous Metabolite,PDE
Solubility	DMSO:45 mg/mL (92.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.09 mM)

Bioactivity

−

Target IC50	PDE4:>1000 nM\|PDE1:180 nM\|PDE5:0.7 nM\|PDE3:>1000 nM\|PDE6:11 nM
In Vivo	Vardenafil significantly induces relaxation of trabecular smooth muscle elicited by both acetylcholine and electrical stimulation. It competitively inhibits phosphodiesterase type 5 (PDE5), thus enhancing the accumulation and relaxation effect of cyclic guanosine monophosphate (cGMP) in vascular smooth muscle. Its IC50 for specifically inhibiting PDE5-mediated cGMP hydrolysis is 0.7 nM (6.6 nM). At 3 nM (10 nM), Vardenafil notably potentiates the relaxation of human trabecular smooth muscle induced by SNP. At 100 mM, Vardenafil significantly increases cGMP levels in rat hippocampus. Read more...
In Vitro	Vardenafil, through the mechanism of mitochondrial K(ATP) channel opening, protects against myocardial ischemia due to reperfusion injury. Oral administration of 3 mg/kg Vardenafil alters object recognition capability in rats. A dose of 30 mg/L orally also upregulates iNOS and proliferating cell nuclear antigen expression (replication of SM cells), leading to the normalization of the rate of dynamic corporal tissue fusion decline and the SM/collagen ratio. Furthermore, Vardenafil induces robust preconditioning-like cardioprotective effects against ischemia/reperfusion injury in rabbits by opening mitochondrial K(ATP) channels. Additionally, it dose-dependently induces an erectile response in rabbits when administered intravenously with Nitroprusside sodium. Read more...

Storage & Handling

−

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Zucker diabetic fatty (ZDF) rats, Vardenafil, Vivanza, stimulation, phosphodiesterase, PED5, cGMP, PDE1, impotence, hepatitis, Levitra, erectile, erectile dysfunction

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

135400189 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Vardenafil (orb1710756)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	224788-34-5
MW:	459.56
Formula:	C₂₂H₂₉N₅O₄S

CAS Number:	448184-58-5
MW:	474.53
Formula:	C₂₁H₂₆N₆O₅S

CAS Number:	1189685-70-8
MW:	493.63
Formula:	C₂₃H₂₇D₅N₆O₄S

CAS Number:	224785-87-9
MW:	474.58
Formula:	C₂₂H₃₀N₆O₄S

CAS Number:	448184-46-1
MW:	460.55
Formula:	C₂₁H₂₈N₆O₄S

Vardenafil

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Pseudovardenafil [orb3143910]

Vardenafil oxopiperazine [orb1740242]

Vardenafil-d5 [orb2299894]

N-Desethyl-N-Methyl Vardenafil (Standard) [orb3025286]

N-Desethyl Vardenafil (Standard) [orb3025287]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Vardenafil (orb1710756)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors