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VEN-02XX

SKU: orb3027921

Description

VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

MW396.79
FormulaC18H16ClF3N4O
SMILESCC(C)(O)CNC1=NN=C(C2=CC=C(Cl)C=C2C(F)(F)F)C3=C1C=NC=C3
TargetNOD-like Receptor (NLR)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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VEN-02XX (orb3027921)

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