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Verteporfin

SKU: orb1304525
FeaturedFeatured Product

Description

Verteporfin is a clinically used photosensitizer and a small molecule inhibitor of the YAP-TEAD protein interaction, a key pathway in the Hippo signaling cascade. It has been widely utilized in research to study oncogenesis, fibrosis, and regenerative processes, demonstrating effects on apoptosis and autophagy in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Stem Cell & Developmental Biology

Images & Validation

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Verteporfin

Key Properties

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CAS Number129497-78-5
MW718.8
Purity>98%
FormulaC41H42N4O8
SMILESCOC(=O)CCc1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(O)=O)c5C)[C@]1(C)[C@H](C(=O)OC)C(=CC=C41)C(=O)OC)c(C)c3C=C
TargetTranscription factor
SolubilitySoluble in DMSO (up to 14 mg/ml)

Bioactivity

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Target IC50
OMM1 cells:5.89 μM|Mel 270 cells:6.43 μM|Omm 2.3 cells:7.27 μM
In Vivo
Verteporfin forms a complex with LDL, which may be taken up by proliferating cells (e.g., neovascular endothelial cells) through LDL receptors or endocytosis. The therapy with Verteporfin achieves complete vascular occlusion through thrombosis in the vascular channels following selective endothelial damage. As shown by optical and electron microscopy, Verteporfin therapy selectively induces occlusion in regenerating and detached choroidal capillaries, without altering the overlying photoreceptors or ganglion cells. Verteporfin rapidly exhibits apoptotic changes in conjunction with light, as demonstrated by the activation of caspase-3 and caspase-9 and the cleavage of PARP in HL-60 cells, changes that are inhibited by the broad-spectrum caspase inhibitor ZVAD.fmk.
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In Vitro
Verteporfin metabolizes into a less active form within the body and is rapidly cleared, primarily excreted via feces and to a lesser extent through urine. Its therapy is effective and selectively prevents fluorescein dye leakage from choroidal neovascularization (CNV) induced in experimental monkeys. Verteporfin quickly accumulates in the choroidal vasculature, retinal pigment epithelium (RPE), and photoreceptors of established rabbit eyes. Upon intravenous injection in mice, peak tissue levels of Verteporfin are reached within 3 hours, followed by a rapid decline within 24 hours.
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Cell Research
Verteporfin is dissolved in DMSO. PDX cells co-cultured with S17 cells are treated with 16 combinations of verteporfin (60 nM, 120 nM, 180 nM, and 240 nM) and dasatinib (12 nM, 24 nM, 36 nM, and 48 nM). The viabilities of cells treated with each combination are measured after 48 h using FACS Aria flow cytometer. In order to estimate drug interaction between verteporfin and dasatinib, a normalized isobologram and fraction affectedcombination index (CI) plot are made using CompuSyn software. CI values greater than 1.0 indicated antagonistic effects, equal to 1.0 additive effects, and below 1.0 synergistic effects.
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Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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CL 318,952; BPD-MA

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  • Verteporfin

    Verteporfin [orb1226601]

    >98% (HPLC)

    129497-78-5

    718.79

    C41H42N4O8

    1 g, 2 mg, 25 mg, 5 mg, 10 mg, 100 mg, 50 mg, 500 mg, 200 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
91181808 ↗

Key Properties

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No computed properties available.

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Verteporfin (orb1304525)

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5 mg
$ 210.00
25 mg
$ 480.00
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