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VGX-1027

SKU: orb1307395

Description

VGX-1027

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number6501-72-0
MW205.21
Purity99.86%
FormulaC11H11NO3
SMILESOC(=O)CC1CC(=NO1)c1ccccc1
TargetIL Receptor,Interleukin,TNF
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.75 mM);DMSO:20.5 mg/mL (99.9 mM)

Bioactivity

In Vivo
VGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines.
In Vitro
VGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TNF-α, TNFR, TNF Receptor, Tumor Necrosis Factor Receptor, VGX 1027, VGX1027, VGX-1027, GIT 27, GIT27, GIT-27, Interleukin Related, Interleukin, Inhibitor, IL Receptor, IL-10, ILReceptor, IL-1β, inhibit

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Key Properties

No computed properties available.

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VGX-1027 (orb1307395)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 90.00
25 mg
$ 130.00
50 mg
$ 180.00
100 mg
$ 260.00
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