VGX-1027

SKU: orb1307395

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Description

VGX-1027

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	6501-72-0
MW	205.2
Purity	>98%
Formula	C₁₁H₁₁NO₃
SMILES	OC(=O)CC1CC(=NO1)c1ccccc1
Target	IL Receptor,Interleukin,TNF
Solubility	Soluble in DMSO (up to 30 mg/ml)

Bioactivity

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In Vivo

VGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines.

In Vitro

VGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GIT 27

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Compound Identifiers

PubChem CID

10798271 ↗

Key Properties

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No computed properties available.

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VGX-1027 (orb1307395)

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Purity:	≥98%
CAS Number:	6501-72-0
MW:	205.21
Formula:	C₁₁H₁₁NO₃

Purity:	>98% (HPLC)
CAS Number:	6501-72-0
MW:	205.21
Formula:	C₁₁H₁₁NO₃

VGX-1027

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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VGX-1027 (orb1307395)

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