Visilizumab Antibody

SKU: orb1980604

Description

Visilizumab is a humanized IgG2 monoclonal antibody targeting CD3 on T-cells with minimized Fc binding to reduce activation-induced cytotoxicity. It modulates T-cell function and has been investigated in preclinical and clinical studies for immune-mediated conditions like ulcerative colitis and Crohn's disease.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	219716-33-3
MW	144.64 kDa
Purity	95.00%
Target	Apoptosis,Others

Bioactivity

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In Vitro	Methods: Visilizumab (1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL, 10,000 ng/mL, 2-48 hours (samples were taken and analyzed at 2, 4, 20, 24, and 48 hours)) was used to treat lamina propria T cells and observe their cell growth. Results: Visilizumab was able to induce dose- and time-dependent apoptosis of lamina propria T cells. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Anti-Human CD3E Recombinant Antibody, HuM291

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Gene Symbol

Apoptosis,Others

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