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Visomitin

SKU: orb1303095

Description

Visomitin

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Visomitin

Key Properties

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CAS Number934826-68-3
MW617.61
Purity99.54%
FormulaC36H42BrO2P
SMILESO=C1C(=CC(=O)C(=C1C)C)CCCCCCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]
TargetReactive Oxygen Species,ROS
SolubilityDMSO:55 mg/mL (89.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.24 mM)

Bioactivity

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In Vivo
In a study on pancreatic ductal adenocarcinoma (PDAC)-bearing mice, continuous treatment with Visomitin (SkQ1) was found to modify systemic angiogenic factors. Specifically, this treatment led to a decrease in serum KC levels and an increase in VEGF molecules, indicating altered angiogenesis. Additionally, Visomitin treatment resulted in reduced levels of MIP1a and prolactin, alongside elevated amounts of IL-6 and IL-13. The pretreatment setting showed a decrease in TGF-b levels. Contrarily, Visomitin treatment across all protocols reduced the percentage of NKT cells. Although the median survival of PDAC-bearing mice was prolonged with Visomitin treatment, the survival increase did not achieve statistical significance.
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In Vitro
Direct treatment of tumor infiltrating leukocytes with Visomitin (SkQ1) does not influence their cytotoxicity against Panc02 cells. Visomitin reduces heavily the proliferation of human PDAC cells at 500 nM concentration while not affecting the viability of the cell lines.
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Cell Research
Panc02 cells are treated 48 h with different concentrations of Visomitin (SkQ1). Cell viability after Visomitin treatment is measured with an EZ4U Kit as described by the manufacturers. Brie y, 20,000 cells per well are seeded in 96-wellplates and let grow overnight. Afterwards, cells are treated without the medium exchange. A substrate compound from the kit is added and the cells are further incubated for 5 hr at 37°C to convert the yellow colored tetrazolium to its red formazan derivate by living cells. The absorbance is measured at 450 nm
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Animal Research
Female C57BL/6 mice are used in this study. For experiments on both acute and chronic pancreatitis, mice are divided in three groups. Group A (acute pancreatitis (AP) n=8; chronic pancreatitis (CP) n=12) is treated with 5 nmol/kg Visomitin (SkQ1), group B (AP n=8; CP n=12) is the untreated control, and group C (AP n=8; CP n=7) is the sham group, which is injected intraperitoneally with 0.9% NaCl instead of cerulein and is therefore the negative control group without pancreatitis. For experiments on acute pancreatitis, mice are pretreated with Visomitin for 8 weeks prior to induction of pancreatitis. Mice designated for experiments on chronic pancreatitis receive Visomitin at the same concentration for 8 weeks in parallel with induction of pancreatitis
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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inhibit, Inhibitor, ReactiveOxygenSpecies, Reactive Oxygen Species, SKQ1, SKQ-1, SKQ 1, Visomitin

Similar Products

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  • SKQ-1 chloride

    SKQ-1 chloride [orb2814920]

    1372443-45-2

    573.14

    C36H42ClO2P

    50 mg, 10 mg
  • Visomitin

    Visomitin [orb1223602]

    >98% (HPLC)

    934826-68-3

    617.61

    C36H42BrO2P

    1 g, 500 mg, 200 mg, 10 mg, 25 mg, 100 mg, 5 mg, 50 mg
Quality Guarantee

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Compound Identifiers

PubChem CID
16679091 ↗

Key Properties

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No computed properties available.

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Visomitin (orb1303095)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 110.00
25 mg
$ 170.00
50 mg
$ 250.00
100 mg
$ 410.00
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