Y-27632 HCl hydrate

SKU: orb1740051

Description

Y-27632 HCl hydrate is an orally active, ATP-competitive inhibitor of ROCK1/ROCK2. It inhibits caspase-3 activity and suppresses stem cell apoptosis, making it a valuable reagent for improving the survival and generation efficiency of induced pluripotent stem cells (iPSCs) in both in vitro culture and in vivo transplantation studies.

Research Area

Cell Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	331752-47-7
MW	338.27
Purity	99.98%
Formula	C₁₄H₂₅Cl₂N₃O₂
SMILES	O=C([C@H]1CC[C@](CC1)([H])[C@H](N)C)NC2=CC=NC=C2.Cl.O.Cl
Target	Apoptosis,Caspase,ROCK

Bioactivity

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Target IC50	ROCK2:300 nM (Ki)\|ROCK1:220 nM (Ki)

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Y 27632, Y27632, Y-27632, Y27632 hydrochloride hydrate

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Compound Identifiers

PubChem CID

9797929 ↗

Key Properties

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No computed properties available.

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