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YM90K

SKU: orb1298936

Description

YM90K hydrochloride is a selective AMPA receptor antagonist. It is a valuable research tool for studying glutamatergic neurotransmission in vitro and has been used in animal models to investigate neurological disorders such as epilepsy and ischemic stroke.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number154164-30-4
MW309.66
Purity>99.99% (May vary between batches)
FormulaC11H8ClN5O4
SMILESCl.[O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1-n1ccnc1
TargetGluR,iGluR
SolubilityDMSO:Slightly soluble

Bioactivity

Target IC50
AMPA receptor:84 nM (Ki)|Kainate receptor:2.2 μM (Ki)|NMDAR:37 μM (Ki)
In Vivo
In a global ischemia model, YM90K (15 mg/kg i.p. x 3), NBQX (30 mg/kg i.p. x 3) and CNQX (60 mg/kg i.p. x 3) significantly prevented the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. In addition, the therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p. x 3) was 6 h. In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduced the volume of ischemic damage in the cerebral cortex in F344 rats.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

YM 90K, YM90K, YM-90K, AMPA, iGluR, ischemia

Similar Products

  • YM90K hydrochloride [orb1220143]

    >98% (HPLC)

    154164-30-4

    309.7

    C11H8ClN5O4

    200 mg, 50 mg, 100 mg, 2 mg, 10 mg, 25 mg, 1 g, 500 mg, 5 mg
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Key Properties

No computed properties available.

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Protocol Information

YM90K (orb1298936)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 120.00
5 mg
$ 220.00
1 ml x 10 mM (in DMSO)
$ 230.00
10 mg
$ 320.00
25 mg
$ 490.00
50 mg
$ 670.00
100 mg
$ 900.00
200 mg
$ 1,170.00
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