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ZL006

SKU: orb1307593

Description

ZL006 is a small molecule that disrupts the nNOS-PSD-95 protein interaction, thereby suppressing excessive nitric oxide production triggered by NMDA receptor activation. It is a valuable research tool for studying excitotoxicity in models of stroke and neurodegenerative diseases, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1181226-02-7
MW328.15
Purity99.75% (May vary between batches)
FormulaC14H11Cl2NO4
SMILESOC(=O)c1ccc(NCc2cc(Cl)cc(Cl)c2O)cc1O
TargetiGluR,NMDAR
SolubilityDMSO:29 mg/mL (88.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.09 mM)

Bioactivity

In Vivo
T7-P-LPs/ZL006 displays a significant enhance in drug accumulation in the brain tissue due to its better brain targeting delivery compared with P-LPs/ZL006 and free ZL006. P-LPs/ZL006 and T7-P-LPs/ZL006 show a significant decrease in drug accumulation in the liver and kidney compared with free ZL006 .
In Vitro
ZL006 growth inhibition of BCECs is not found at a low concentration of 0.001, 0.01, 0.1, 1, and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is obviously enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

iGluR, Inhibitor, NMDA, inhibit, Ionotropic glutamate receptors, ZL 006, ZL006, ZL-006
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

ZL006 (orb1307593)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 90.00
10 mg
$ 110.00
25 mg
$ 160.00
50 mg
$ 230.00
100 mg
$ 370.00
200 mg
$ 510.00
DispatchUsually dispatched within 3-5 working days
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