ZM241385

SKU: orb1300136

Description

ZM-241385 is a potent and selective adenosine A2A receptor antagonist. It is widely used in both in vitro and in vivo research to study adenosine signaling in fields such as neuroscience, immunology, and cardiovascular physiology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	139180-30-6
MW	337.34
Purity	99.69% (May vary between batches)
Formula	C₁₆H₁₅N₇O₂
SMILES	Nc1nc(NCCc2ccc(O)cc2)nc2nc(nn12)-c1ccco1
Target	Adenosine Receptor
Solubility	DMSO:120 mg/mL (355.72 mM);Ethanol:1.7 mg/mL (5.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.82 mM)

Bioactivity

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Target IC50	A2A receptor:1.4 nM (Ki)
In Vivo	ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists. Read more...
In Vitro	ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7 min) OGD period, and protect CA1 neuron and astrocyte from injury. Read more...
Cell Research	Nitric oxide (NO) production is assessed by measuring the amount of nitrite, a stable metabolic product of NO that provides an indirect measurement of NO, by using the Griess diazotization reaction. Briefly, 24 h after incubation with 1.0 µM CG21680 or 1.0 µM ZM241385 or exposure to SMF, samples of medium (150 µl) are collected from cells and mixed with 130 µl dWater and with 20 µl Griess reagent using instruction supplied by the manufacturer. After a 30 min incubation period at room temperature, the samples are evaluated spectrophotometrically at 548 nm and OD values-in comparison with a standard curve is determined in culture medium by using serial dilutions of sodium nitrite-represented total stable metabolites of NO. (Only for Reference) Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, AdenosineReceptor, Adenosine Receptor, A2A, ZM241385, ZM-241385, ZM 241385, P1 receptor

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Compound Identifiers

PubChem CID

176407 ↗

Key Properties

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No computed properties available.

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ZM241385 (orb1300136)

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MW:	399.47
Formula:	C₁₉H₂₁N₅O₃S

ZM241385

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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