1-(1-Naphthyl)piperazine

SKU: orb3174259

Description

1-(1-Naphthyl)piperazine is a modulator of 5-HT receptors, acting both as a 5-HT2A receptor antagonist and a 5-HT1A receptor agonist, with a human 5-HT6 receptor binding constant (Ki) of 120 nM. It partially inhibits forskolin-stimulated adenylate cyclase activity in bovine substantia nigra and can suppress UV radiation-induced immunosuppression. Additionally, 1-(1-Naphthyl)piperazine induces S-phase cell cycle delay, apoptosis, and increases reactive oxygen species (ROS) levels, leading to the inhibition of MNT-1 cell proliferation. This compound is utilized in melanoma research.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	57536-86-4
MW	212.2902
Formula	C₁₄H₁₆N₂
SMILES	C1CN(CCN1)C1=C2C=CC=CC2=CC=C1
Target	5-HT Receptor,AChR,ROS,Apoptosis

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

5-HT Receptor,AChR,ROS,Apoptosis

Protocol Information

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